Biolets
– Random Sequence Generator
This is a small but useful Java based tool, for those
who are interested in bio-sequence analysis. Biolets
is a biological sequence generator using which DNA,
RNA and Protein sequences can be generated. It incorporates
various probability distribution functions for generating
random numbers which are then mapped into either nucleotides
or amino acids as per user selection. Third position
control in codons, GC base pair control, Tandem repeats
control and Supersede control are some of the features
included in Biolets.  There
are options for users to set the percentages of purines,
pyrimidines, nucleotides and amino acids in the sequence
to be generated, type of the sequence to be generated
etc. The feature which gives an edge to Biolets over
similar existing tools is the Energy calculation. This
tool calculates the energy associated with the sequence
generated using Gibbs free energy. This tool gives absolute
control over nucleotides /amino acids to be generated.
This tool can be the first member in a complete bio-sequence
analysis suite. The range of applications of this tool
can be from simple bio-sequence generation to synthetic
biology like designing a bio-sequence according to your
wish!
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